Article
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.
Nature communications - 13 Jun 2018
Gusarova Viktoria, O'Dushlaine Colm, Teslovich Tanya M, Benotti Peter N, Mirshahi Tooraj, Gottesman Omri, Van Hout Cristopher V, Murray Michael F, Mahajan Anubha, Nielsen Jonas B, Fritsche Lars, Wulff Anders Berg, Gudbjartsson Daniel F, Sjögren Marketa, Emdin Connor A, Scott Robert A, Lee Wen-Jane, Small Aeron, Kwee Lydia C, Dwivedi Om Prakash, Prasad Rashmi B, Bruse Shannon, Lopez Alexander E, Penn John, Marcketta Anthony, Leader Joseph B, Still Christopher D, Kirchner H Lester, Mirshahi Uyenlinh L, Wardeh Amr H, Hartle Cassandra M, Habegger Lukas, Fetterolf Samantha N, Tusie-Luna Teresa, Morris Andrew P, Holm Hilma, Steinthorsdottir Valgerdur, Sulem Patrick, Thorsteinsdottir Unnur, Rotter Jerome I, Chuang Lee-Ming, Damrauer Scott, Birtwell David, Brummett Chad M, Khera Amit V, Natarajan Pradeep, Orho-Melander Marju, Flannick Jason, Lotta Luca A, Willer Cristen J, Holmen Oddgeir L, Ritchie Marylyn D, Ledbetter David H, Murphy Andrew J, Borecki Ingrid B, Reid Jeffrey G, Overton John D, Hansson Ola, Groop Leif, Shah Svati H, Kraus William E, Rader Daniel J, Chen Yii-Der I, Hveem Kristian, Wareham Nicholas J, Kathiresan Sekar, Melander Olle, Stefansson Kari, Nordestgaard Børge G, Tybjærg-Hansen Anne, Abecasis Goncalo R, Altshuler David, Florez Jose C, Boehnke Michael, McCarthy Mark I, Yancopoulos George D, Carey David J, Shuldiner Alan R, Baras Aris, Dewey Frederick E, Gromada Jesper
Abstract excerpt
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and decrease risk of type 2 diabetes (T2D). We investigate protein-altering variants in ANGPTL4 among 58,124 participants in the DiscovEHR human genetics study, with...
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