Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.

doi:10.1056/NEJMoa1510926

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Article

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.

The New England journal of medicine - 24 Mar 2016

Dewey Frederick E, Gusarova Viktoria, O'Dushlaine Colm, Gottesman Omri, Trejos Jesus, Hunt Charleen, Van Hout Cristopher V, Habegger Lukas, Buckler David, Lai Ka-Man V, Leader Joseph B, Murray Michael F, Ritchie Marylyn D, Kirchner H Lester, Ledbetter David H, Penn John, Lopez Alexander, Borecki Ingrid B, Overton John D, Reid Jeffrey G, Carey David J, Murphy Andrew J, Yancopoulos George D, Baras Aris, Gromada Jesper, Shuldiner Alan R

Abstract excerpt

BACKGROUND: Higher-than-normal levels of circulating triglycerides are a risk factor for ischemic cardiovascular disease. Activation of lipoprotein lipase, an enzyme that is inhibited by angiopoietin-like 4 (ANGPTL4), has been shown to reduce levels of circulating triglycerides. METHODS: We sequenced the exons of ANGPTL4 in samples obtain from 42,930 participants of predominantly European ancestry in the...

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PMID: 26933753
DOI: 10.1056/NEJMoa1510926
PMCID: PMC4900689

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ANGPTL4

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