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Article

Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication.

DNA repair - 1 Jun 2007

Krishna Sanchita, Wagener Brant M, Liu Hui Ping, Lo Yi-Chen, Sterk Rosa, Petrini John H J, Nickoloff Jac A

Abstract excerpt

The yeast Mre11-Rad50-Xrs2 (MRX) and Ku complexes regulate single-strand resection at DNA double-strand breaks (DSB), a key early step in homologous recombination (HR). A prior plasmid gap repair study showed that mre11 mutations, which slow single-strand resection, reduce gene conversion tract lengths and the frequency of associated crossovers. Here we tested whether mre11Delta or nuclease-defective mre11...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17321803
DOI: 10.1016/j.dnarep.2007.01.006
PMCID: PMC1948817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication.PMID 17321803Read ↗

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