Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of Rad51 inhibits double-strand break-induced homologous recombination but does not affect gene conversion tract lengths.

DNA repair - 8 Jun 2005

Paffett Kimberly S, Clikeman Jennifer A, Palmer Sean, Nickoloff Jac A

Abstract excerpt

DNA double-strand breaks (DSBs) in yeast are repaired by homologous recombination (HR) and non-homologous end-joining (NHEJ). Rad51 forms nucleoprotein filaments at processed broken ends that effect strand exchange, forming heteroduplex DNA (hDNA) that gives rise to a gene conversion tract. We hypothesized that excess Rad51 would increase gene conversion tract lengths. We found that excess Rad51 reduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Fungal
Share to DNA Helicases
Share to Gene Conversion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

Share to Genomic Instability

Share to Methyl Methanesulfonate

Share to Mutagens

Share to Rad51 Recombinase

Source

Identifiers

PMID: 15878310
DOI: 10.1016/j.dnarep.2005.03.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of Rad51 inhibits double-strand break-induced homologous recombination but does not affect gene conversion tract lengths.PMID 15878310Read ↗

Spontaneous and double-strand break-induced recombination, and gene conversion tract lengths, are differentially affected by overexpression of wild-type or ATPase-defective yeast Rad54.Semantic proximity Read ↗

Interaction of yeast Rad51 and Rad52 relieves Rad52-mediated inhibition of de novo telomere addition.Semantic proximity Read ↗

Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication.Semantic proximity Read ↗

Novel insights into RAD51 activity and regulation during homologous recombination and DNA replicationSemantic proximity Read ↗

Srs2 and Mus81-Mms4 Prevent Accumulation of Toxic Inter-Homolog Recombination Intermediates.Semantic proximity Read ↗

Rad52-Rad51 association is essential to protect Rad51 filaments against Srs2, but facultative for filament formation.Semantic proximity Read ↗

A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio.Semantic proximity Read ↗

Homologous recombinational repair of double-strand breaks in yeast is enhanced by MAT heterozygosity through yKU-dependent and -independent mechanisms.Semantic proximity Read ↗

Rad51 determines pathway usage in post-replication repair.Semantic proximity Read ↗

Overlapping mechanisms promote postsynaptic RAD-51 filament disassembly during meiotic double-strand break repair.Semantic proximity Read ↗

Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells.Semantic proximity Read ↗

Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.