Extensive DNA end processing by exo1 and sgs1 inhibits break-induced replication.

doi:10.1371/journal.pgen.1001007

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Article

Extensive DNA end processing by exo1 and sgs1 inhibits break-induced replication.

PLoS genetics - 8 Jul 2010

Marrero Vanessa A, Symington Lorraine S

Abstract excerpt

Homology-dependent repair of DNA double-strand breaks (DSBs) by gene conversion involves short tracts of DNA synthesis and limited loss of heterozygosity (LOH). For DSBs that present only one end, repair occurs by invasion into a homologous sequence followed by replication to the end of the chromosome resulting in extensive LOH, a process called break-induced replication (BIR). We developed a BIR assay in...

Topics

Chromosome Aberrations
Chromosomes, Fungal
DNA
DNA Breaks, Double-Stranded
DNA Repair
DNA Replication
Exodeoxyribonucleases
Mutation
RecQ Helicases
Recombination, Genetic
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 20628570
DOI: 10.1371/journal.pgen.1001007
PMCID: PMC2900301

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