Article
High T-helper-1 cytokines but low T-helper-3 cytokines, inflammatory cytokines and chemokines in children with high risk of developing type 1 diabetes.
Diabetes/metabolism research and reviews - 1 Sept 2007
Stechova Katerina, Bohmova Kristyna, Vrabelova Zuzana, Sepa Annelie, Stadlerova Gabriela, Zacharovova Klara, Faresjö Maria
Abstract excerpt
BACKGROUND: Type 1 diabetes (T1D) is suggested to be of T-helper (Th)1-like origin. However, recent reports indicate a diminished interferon (IFN)-gamma secretion at the onset of the disease. We hypothesize that there is a discrepancy in subsets of Th-cells between children with a high risk of developing T1D, children newly diagnosed with T1D and healthy children. METHODS: Peripheral blood mononuclear cells...
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