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Article

The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children.

Pediatric diabetes - 1 Aug 2007

Jonson Carl-Oscar, Lernmark Ake, Ludvigsson Johnny, Rutledge Elizabeth A, Hinkkanen Ari, Faresjö Maria

Abstract excerpt

BACKGROUND: Type 1 diabetes (T1D) is an autoimmune disease associated with the destruction of pancreatic beta cells and genetically linked to human leukocyte antigen (HLA) class II DR3-DQ2 and DR4-DQ8 haplotypes. The +49A/G polymorphism of the immunoregulatory cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene is also associated with T1D. Genetic and environmental risk factors precede the onset of T1D, which is...

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Identifiers

PMID: 17659059
DOI: 10.1111/j.1399-5448.2007.00245.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children.PMID 17659059Read ↗

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