Article
[The level of circulating cytokines and chemokines in the preclinical and early clinical stages of type IA diabetes mellitus development].
Terapevticheskii arkhiv - 1 Jan 2010
Zak K P, Popova V V, Mel'nichenko S V, Tron'ko E N, Man'kovskiĭ B N
Abstract excerpt
AIM: to study the level of circulating proinflammatory (IL-1alpha, IL-1beta, IL-6, alpha-TNF, IFN-gamma) and anti-inflammatory (IL-4, IL-10) cytokines and chemokines (IL-8, IL-16) in preclinical development of type 1A diabetes mellitus (T1DM) in children. SUBJECTS AND METHODS: An examination was made in 450 children who had normal blood glucose levels and a burdened history of positive or negative Langerhans...
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