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Article

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells.

Nature genetics - 1 Mar 2007

Chen Taiping, Hevi Sarah, Gay Frédérique, Tsujimoto Naomi, He Timothy, Zhang Bailin, Ueda Yoshihide, Li En

Abstract excerpt

Studies have shown that DNA (cytosine-5-)-methyltransferase 1 (DNMT1) is the principal enzyme responsible for maintaining CpG methylation and is required for embryonic development and survival of somatic cells in mice. The role of DNMT1 in human cancer cells, however, remains highly controversial...

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Source

Identifiers

PMID: 17322882
DOI: 10.1038/ng1982

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17322882-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells.PMID 17322882Read ↗

DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells.Semantic proximity Read ↗

DNA hypomethylation leads to elevated mutation rates.Semantic proximity Read ↗

GSK-3484862 targets DNMT1 for degradation in cellsSemantic proximity Read ↗

DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes.Semantic proximity Read ↗

Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern.Semantic proximity Read ↗

Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers.Semantic proximity Read ↗

DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage responseSemantic proximity Read ↗

The ‘de novo’ DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epitheliumSemantic proximity Read ↗

Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway.Semantic proximity Read ↗

5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal.Semantic proximity Read ↗

5-aza-2'-deoxycytidine-induced genome rearrangements are mediated by DNMT1.Semantic proximity Read ↗

Stability of XIST repression in relation to genomic imprinting following global genome demethylation in a human cell line.Semantic proximity Read ↗

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