Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>In vivo</i> stabilization of the Dnmt1 (cytosine-5)- methyltransferase protein

23 Oct 2002

Abstract excerpt

The Dnmt1o form of the Dnmt1 (cytosine-5)-methyltransferase enzyme is synthesized and stored in the cytoplasm of the oocyte and is used after fertilization to maintain methylation patterns on imprinted genes. After implantation of the blastocyst, Dnmt1o is replaced by the Dnmt1 form, which has an additional 118 aa at its amino terminus. To investigate functional differences between Dnmt1o and Dnmt1, mice were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12397175
DOI: 10.1073/pnas.232565599

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>In vivo</i> stabilization of the Dnmt1 (cytosine-5)- methyltransferase proteinPMID 12397175Read ↗

Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.Semantic proximity Read ↗

Identification of a region of the DNMT1 methyltransferase that regulates the maintenance of genomic imprints.Semantic proximity Read ↗

Preimplantation expression of the somatic form of Dnmt1 suggests a role in the inheritance of genomic imprintsSemantic proximity Read ↗

Profound phenotypic variation among mice deficient in the maintenance of genomic imprints.Semantic proximity Read ↗

Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in FemalesSemantic proximity Read ↗

Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila.Semantic proximity Read ↗

Sex-specific exons control DNA methyltransferase in mammalian germ cellsSemantic proximity Read ↗

The DNMT1 intrinsically disordered domain regulates genomic methylation during development.Semantic proximity Read ↗

Dynamics of Dnmt1 Methyltransferase Expression and Intracellular Localization during Oogenesis and Preimplantation DevelopmentSemantic proximity Read ↗

Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions.Semantic proximity Read ↗

DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells.Semantic proximity Read ↗

DNMT1 can induce primary germ layer differentiation through de novo DNA methylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.