Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity.

doi:10.1128/JVI.66.2.757-765.1992

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Article

Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity.

Journal of virology - 1 Feb 1992

de Jong J J, Goudsmit J, Keulen W, Klaver B, Krone W, Tersmette M, de Ronde A

Abstract excerpt

Chimeric human immunodeficiency virus type 1 (HIV-1) molecular clones differing only in the envelope V3 region were constructed. The V3 regions were derived from two HIV-1 isolates with a non-syncytium-inducing, non-T-cell-tropic phenotype and from four HIV-1 isolates with a syncytium-inducing, T-cell-tropic phenotype. When assayed in SupT1 cells, the two chimeric viruses with a V3 region derived from the...

Topics

Amino Acid Sequence
Base Sequence
Cell Line
Cells, Cultured
Chimera
Cloning, Molecular
Genetic Variation
Giant Cells
HIV Envelope Protein gp120
HIV-1
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenesis, Site-Directed

Oligodeoxyribonucleotides

Plasmids

Polymerase Chain Reaction

Restriction Mapping

T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 1731110
DOI: 10.1128/JVI.66.2.757-765.1992
PMCID: PMC240775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1731110-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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