Article
Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule.
Journal of virology - 1 May 1992
Fouchier R A, Groenink M, Kootstra N A, Tersmette M, Huisman H G, Miedema F, Schuitemaker H
Abstract excerpt
The third variable (V3) domain has been implicated in determining the human immunodeficiency virus (HIV) phenotype, including fusion capacity and monocytotropism. In a large set of primary HIV type 1 (HIV-1) isolates, V3 sequence analysis revealed that fast-replicating, syncytium-inducing isolate...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Cell Fusion
- Genetic Variation
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Molecular Sequence Data
- Phenotype
- Protein Conformation
- Sequence Homology, Nucleic Acid
- Structure-Activity Relationship