Article
HIV-1 evolves into a nonsyncytium-inducing virus upon prolonged culture in vitro.
Virology - 10 Oct 1999
Das A T, Land A, Braakman I, Klaver B, Berkhout B
Abstract excerpt
HIV-1 LAI is a syncytium-inducing (SI) virus with a broad host cell range. We previously isolated a LAI variant that improved replication in the SupT1 T cell line due to mutations within the C1 and C4 constant regions of the Env protein. We now report that this variant exhibits a severely restricted host cell range, as replication in other T cell lines and primary cells was abolished. Several Env-mediated...
Topics
- Adaptation, Physiological
- Cell Line
- Cytopathogenic Effect, Viral
- Giant Cells
- HIV-1
- Humans
- Mutation
- T-Lymphocytes
- Viral Envelope Proteins
- Virus Cultivation
- Virus Replication