Simple determination of human immunodeficiency virus type 1 syncytium-inducing V3 genotype by PCR.

doi:10.1128/jcm.33.4.906-911.1995

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Simple determination of human immunodeficiency virus type 1 syncytium-inducing V3 genotype by PCR.

Journal of clinical microbiology - 1 Apr 1995

Fouchier R A, Brouwer M, Broersen S M, Schuitemaker H

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) phenotype variability plays an important role in the pathogenesis of AIDS. The presence of syncytium-inducing (SI) HIV-1 isolates in infected individuals is associated with a rapid decline of CD4+ T cells, rapid disease progression, and reduced survival time after AIDS diagnosis. The strong association between the SI capacity of HIV-1 and the presence of positively...

Topics

Amino Acid Sequence
Base Sequence
Cytopathogenic Effect, Viral
DNA Primers
DNA, Viral
Genetic Variation
Genotype
HIV Envelope Protein gp120
HIV Infections
HIV-1
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Peptide Fragments

Phenotype

Polymerase Chain Reaction

Sensitivity and Specificity

Sequence Homology, Amino Acid

Virology

Source

Open in PubMed Open full text

Identifiers

PMID: 7790458
DOI: 10.1128/jcm.33.4.906-911.1995
PMCID: PMC228065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7790458-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simple determination of human immunodeficiency virus type 1 syncytium-inducing V3 genotype by PCR.PMID 7790458Read ↗

Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule.Semantic proximity Read ↗

Maintenance of syncytium-inducing phenotype of HIV type 1 is associated with positively charged residues in the HIV type 1 gp120 V2 domain without fixed positions, elongation, or relocated N-linked glycosylation sites.Semantic proximity Read ↗

Relationship between V3 genotype, biologic phenotype, tropism, and coreceptor use for primary isolates of human immunodeficiency virus type 1.Semantic proximity Read ↗

Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution.Semantic proximity Read ↗

Syncytium-inducing and non-syncytium-inducing capacity of human immunodeficiency virus type 1 subtypes other than B: phenotypic and genotypic characteristics. WHO Network for HIV Isolation and Characterization.Semantic proximity Read ↗

V3 loop sequence analysis of seven HIV type 1 group O isolates phenotyped in peripheral blood mononuclear cells and MT-2 cells.Semantic proximity Read ↗

A reliable phenotype predictor for human immunodeficiency virus type 1 subtype C based on envelope V3 sequences.Semantic proximity Read ↗

Predicting HIV-1 coreceptor usage with sequence analysis.Semantic proximity Read ↗

Positioning of positively charged residues in the V3 loop correlates with HIV type 1 syncytium-inducing phenotype.Semantic proximity Read ↗

HIV type 1 V3 variation dynamics in vivo: long-term persistence of non-syncytium-inducing genotypes and transient presence of syncytium-inducing genotypes during the course of progressive AIDS.Semantic proximity Read ↗

A group of V3 sequences from human immunodeficiency virus type 1 subtype E non-syncytium-inducing, CCR5-using variants are resistant to positive selection pressure.Semantic proximity Read ↗

HIV-1 viraemia changes in patients with and without syncytium-inducing phenotype treated with nucleoside analogues: a case-control study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.