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Article

Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution.

Journal of virology - 1 Nov 1992

De Jong J J, De Ronde A, Keulen W, Tersmette M, Goudsmit J

Abstract excerpt

The third variable domain (V3) of the human immunodeficiency virus type 1 external envelope contains determinants of cell tropism, cytopathicity, and infectivity and elicits antibodies able to block infectivity in vitro and in vivo. Our study encompassed point-mutational analysis of HXB-2 viruses containing patient-derived V3 regions and expressing a non-syncytium-inducing, low-replicating phenotype in T-cell...

Topics

Amino Acid Sequence
Arginine
Aspartic Acid
Cell Fusion
Genetic Variation
Glutamine
HIV Envelope Protein gp120
HIV-1
Molecular Sequence Data
Phenotype
Serine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Viral Fusion Proteins

Source

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Identifiers

PMID: 1404617
DOI: 10.1128/JVI.66.11.6777-6780.1992
PMCID: PMC240176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1404617-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution.PMID 1404617Read ↗

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