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Article

Phenotypic switch in a Spanish HIV type 1 isolate on serial passage on MT-4 cells.

AIDS research and human retroviruses - 20 Jul 1997

Olivares I, Shaw G, Lopez-Galindez C

Abstract excerpt

A biological clone (F0) of a syncytium-inducing (SI) isolate (S61) was unable to produce syncytia in MT-4 cells. On serial passage on MT-4 cells this virus [F15(-3)] became capable of inducing syncytia (Sánchez-Palomino S, et al.: J Virol 1993;67:2938). After sequencing different regions of the env gene including V1-V2, V3, and the fusion domain of both viruses, we have found only an asparagine (N)-to-isoleucine...

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Identifiers

PMID: 9223414
DOI: 10.1089/aid.1997.13.979

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