Impact of natural sequence variation in the V2 region of the envelope protein of human immunodeficiency virus type 1 on syncytium induction: a mutational analysis.

doi:10.1099/0022-1317-76-8-1901

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Article

Impact of natural sequence variation in the V2 region of the envelope protein of human immunodeficiency virus type 1 on syncytium induction: a mutational analysis.

The Journal of general virology - 1 Aug 1995

Andeweg A C, Boers P H, Osterhaus A D, Bosch M L

Abstract excerpt

Several studies have demonstrated a functional role for the V1-V2 region of the human immunodeficiency virus type 1 (HIV-1) envelope surface glycoprotein gp120 in the membrane fusion processes underlying viral entry and syncytium induction. In a study with chimeric primary envelope genes, we have previously demonstrated that the exchange of V2 regions was sufficient to transfer syncytium-inducing capacity to a...

Topics

Amino Acid Sequence
Amino Acids
Base Sequence
Cells, Cultured
Electrochemistry
Genes, env
Genetic Variation
Giant Cells
HIV Envelope Protein gp120
HIV-1
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Fusion

Molecular Sequence Data

Mutation

Protein Structure, Secondary

Recombinant Fusion Proteins

T-Lymphocytes, Regulatory

Transfection

Source

Open in PubMed

Identifiers

PMID: 7636471
DOI: 10.1099/0022-1317-76-8-1901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7636471-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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