Article
Determinants for the syncytium-inducing phenotype of HIV-1 subtype F isolates are located in the V3 region.
AIDS research and human retroviruses - 10 Jun 2000
Holm-Hansen C, Baan E, Asjö B, Pascu F R, Goudsmit J, De Jong J J
Abstract excerpt
The HIV-1 syncytium-inducing phenotype is determined by virus replication and the presence of cytopathic effects in MT-2 cells. There is a strong correlation between the syncytium-inducing/MT-2-tropic phenotype and positively charged amino acids at positions 306 and 320 in the V3 loop for HIV-1 subtypes A, B, D, and E. In contrast, a lack of correlation between signature amino acids and syncytium formation in...
Topics
- Amino Acid Sequence
- Amino Acids
- Cell Line
- Cytopathogenic Effect, Viral
- Electrochemistry
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Molecular Sequence Data
- Peptide Fragments
- Phenotype
- Sequence Homology, Amino Acid