Article
Syncytium-inducing and non-syncytium-inducing capacity of human immunodeficiency virus type 1 subtypes other than B: phenotypic and genotypic characteristics. WHO Network for HIV Isolation and Characterization.
AIDS research and human retroviruses - 1 Nov 1994
De Wolf F, Hogervorst E, Goudsmit J, Fenyö E M, Rübsamen-Waigmann H, Holmes H, Galvao-Castro B, Karita E, Wasi C, Sempala S D
Abstract excerpt
Positively charged amino acid substitutions at positions 11 and 25 within the loop of the third variable region (V3) of HIV-1 subtype B envelope have been shown to be associated with the syncytium-inducing (SI) phenotype of the virus. The present study was designed to examine SI and NSI-associated V3 mutations in HIV-1 subtypes other than B. HIV-1 RNA was isolated from 53 virus stocks and 26 homologous plasma...
Topics
- Adult
- Amino Acid Sequence
- Base Sequence
- Brazil
- Cell Line
- Cytopathogenic Effect, Viral
- DNA, Viral
- Female
- Genes, env
- Genotype