Article
Maintenance of syncytium-inducing phenotype of HIV type 1 is associated with positively charged residues in the HIV type 1 gp120 V2 domain without fixed positions, elongation, or relocated N-linked glycosylation sites.
AIDS research and human retroviruses - 1 Oct 1995
Cornelissen M, Hogervorst E, Zorgdrager F, Hartman S, Goudsmit J
Abstract excerpt
The prevalence of HIV-1 sequences of the envelope domains V1V2 and V3 was analyzed by RT-PCR amplification. Two distinct biological phenotypes of HIV-1 have been described: the nonsyncytium-inducing (NSI) phenotype, best characterized by the inability to infect MT-2 cells, and the syncytium-induc...
Topics
- Amino Acid Sequence
- Binding Sites
- Cell Line
- Giant Cells
- Glycosylation
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Molecular Sequence Data
- Peptide Fragments
- Phenotype