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Aurora-A Regulation of Nuclear Factor-κB Signaling by Phosphorylation of IκBα

15 Feb 2007

Abstract excerpt

The Aurora-A/STK15 gene encodes a kinase that is frequently amplified in cancer. Overexpression of Aurora-A in mammalian cells leads to centrosome amplification, genetic instability, and transformation. In this study, we show that Aurora-A activates nuclear factor-kappaB (NF-kappaB) via IkappaBalpha phosphorylation. Inhibition of endogenous Aurora-A reduces tumor necrosis factor alpha (TNFalpha)-induced...

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PMID: 17308110
DOI: 10.1158/0008-5472.can-06-2272

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