Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aurora B kinase phosphorylates and instigates degradation of p53

18 May 2012

Abstract excerpt

Aurora B is a mitotic checkpoint kinase that plays a pivotal role in the cell cycle, ensuring correct chromosome segregation and normal progression through mitosis. Aurora B is overexpressed in many types of human cancers, which has made it an attractive target for cancer therapies. Tumor suppressor p53 is a genome guardian and important negative regulator of the cell cycle. Whether Aurora B and p53 are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22611192
DOI: 10.1073/pnas.1110287109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aurora B kinase phosphorylates and instigates degradation of p53PMID 22611192Read ↗

Functional Significance of Aurora Kinases–p53 Protein Family Interactions in CancerSemantic proximity Read ↗

Biology of Aurora A kinase: Implications in cancer manifestation and therapySemantic proximity Read ↗

Aurora B: A new promising therapeutic target in cancerSemantic proximity Read ↗

Aurora Kinases: New Targets for Cancer TherapySemantic proximity Read ↗

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant stateSemantic proximity Read ↗

Aurora B Inhibitors as Cancer TherapeuticsSemantic proximity Read ↗

Roles of Aurora kinases in mitosis and tumorigenesis.Semantic proximity Read ↗

The Aurora kinases: role in cell transformation and tumorigenesis.Semantic proximity Read ↗

Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for CancerSemantic proximity Read ↗

Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapySemantic proximity Read ↗

Aurora-A Kinase as a Promising Therapeutic Target in CancerSemantic proximity Read ↗

Aurora B Overexpression Causes Aneuploidy and p21 Cip1 Repression during Tumor DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.