Article
Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice.
Chemical research in toxicology - 1 Feb 2006
Welch Kevin D, Reilly Timothy P, Bourdi Mohammed, Hays Thomas, Pise-Masison Cynthia A, Radonovich Michael F, Brady John N, Dix David J, Pohl Lance R
Abstract excerpt
Drug-induced liver disease (DILD) continues to cause significant morbidity and mortality and impair new drug development. Mounting evidence suggests that DILD is a complex, multifactorial disease in which no one factor is likely to be an absolute indicator of susceptibility. As an approach to better understand the multifactorial basis of DILD, we recently compared the hepatic proteomes of mice that were resistant...
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