Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Srcasm corrects Fyn-induced epidermal hyperplasia by kinase down-regulation.

The Journal of biological chemistry - 12 Jan 2007

Li Weijie, Marshall Christine, Mei Lijuan, Gelfand Joel, Seykora John T

Abstract excerpt

Src family tyrosine kinases (SFKs) are important regulators of epithelial cell growth and differentiation. Characterization of cellular mechanisms that regulate SFK activity will provide insights into the pathogenesis of diseases associated with increased SFK activity. Keratin 14-Fyn (K14) transgenic mice were derived to characterize the effect of Fyn on epidermal growth and differentiation in vivo. The epidermis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3-Phosphoinositide-Dependent Protein Kinases
Share to Epidermis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hyperplasia

Share to Keratin-14

Share to Mice, Inbred CBA

Share to Proto-Oncogene Proteins c-fyn

Share to Skin Diseases

Share to src-Family Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 17046829
DOI: 10.1074/jbc.M606583200
PMCID: PMC3099404

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Srcasm corrects Fyn-induced epidermal hyperplasia by kinase down-regulation.PMID 17046829Read ↗

Src family kinases phosphorylate protein kinase C delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes.Semantic proximity Read ↗

C-terminal Src kinase controls development and maintenance of mouse squamous epithelia.Semantic proximity Read ↗

Proteomic Analysis of Src Family Kinase Phosphorylation States in Cancer Cells Suggests Deregulation of the Unique Domain.Semantic proximity Read ↗

FYNagling divergent adhesive functions for Fyn in keratinocytes.Semantic proximity Read ↗

FYN: emerging biological roles and potential therapeutic targets in cancerSemantic proximity Read ↗

Overexpression of a constitutively active form of c-src in skin epidermis increases sensitivity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.Semantic proximity Read ↗

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.Semantic proximity Read ↗

Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells.Semantic proximity Read ↗

Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells.Semantic proximity Read ↗

Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways.Semantic proximity Read ↗

Impaired keratinocyte proliferative and clonogenic potential in transgenic mice overexpressing 14-3-3σ in the epidermis.Semantic proximity Read ↗

The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.