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Article

The Syk Tyrosine Kinase Is Required for Skin Inflammation in an In Vivo Mouse Model of Epidermolysis Bullosa Acquisita.

The Journal of investigative dermatology - 1 Oct 2017

Németh Tamás, Virtic Oana, Sitaru Cassian, Mócsai Attila

Abstract excerpt

The inflammatory form of epidermolysis bullosa acquisita is caused by autoantibodies against type VII collagen (C7), a component of the dermal-epidermal junction. We have previously shown that myeloid Src family kinases mediate skin inflammation triggered by anti-C7 antibodies. Here we identify the Syk tyrosine kinase as a critical component of autoantibody-induced skin inflammation downstream of Src family...

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Source

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Identifiers

PMID: 28576735
DOI: 10.1016/j.jid.2017.05.017
PMCID: PMC5624865

Genes

CXCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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