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Article

RAC1 activation drives pathologic interactions between the epidermis and immune cells.

The Journal of clinical investigation - 1 Jul 2016

Winge Mårten C G, Ohyama Bungo, Dey Clara N, Boxer Lisa M, Li Wei, Ehsani-Chimeh Nazanin, Truong Allison K, Wu Diane, Armstrong April W, Makino Teruhiko, Davidson Matthew, Starcevic Daniela, Kislat Andreas, Nguyen Ngon T, Hashimoto Takashi, Homey Bernard, Khavari Paul A, Bradley Maria, Waterman Elizabeth A, Marinkovich M Peter

Abstract excerpt

Interactions between the epidermis and the immune system govern epidermal tissue homeostasis. These epidermis-immune interactions are altered in the inflammatory disease psoriasis; however, the pathways that underlie this aberrant immune response are not well understood. Here, we determined that Ras-related C3 botulinum toxin substrate 1 (RAC1) is a key mediator of epidermal dysfunction. RAC1 activation was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27294528
DOI: 10.1172/JCI85738
PMCID: PMC4922704

Genes

RAC1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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