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Article

Genetic variation in the premature aging gene WRN: a case-control study on breast cancer susceptibility.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2007

Ding Shian-ling, Yu Jyh-Cherng, Chen Shou-Tung, Hsu Giu-Cheng, Shen Chen-Yang

Abstract excerpt

The high risk of developing cancer seen in human genetic diseases that resemble accelerated aging provides support for a tumorigenic contribution of the mechanisms and genes responsible for regulating life span and aging. We therefore speculated that the WRN gene (encoding RECQL2, a DNA helicase), the germline mutation of which causes the progeroid disorder Werner syndrome, may be associated with breast...

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Source

Identifiers

PMID: 17301258
DOI: 10.1158/1055-9965.EPI-06-0678

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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