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Article

Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer.

Carcinogenesis - 1 Aug 2006

Wirtenberger Michael, Frank Bernd, Hemminki Kari, Klaes Rüdiger, Schmutzler Rita K, Wappenschmidt Barbara, Meindl Alfons, Kiechle Marion, Arnold Norbert, Weber Bernhard H F, Niederacher Dieter, Bartram Claus R, Burwinkel Barbara

Abstract excerpt

Mutations of the human RecQ helicase genes WRN and BLM lead to rare autosomal recessive disorders, Werner and Bloom syndromes, which are associated with premature ageing and cancer predisposition. We tested the hypothesis whether three polymorphic, non-conservative amino acid exchanges in WRN and...

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Source

Identifiers

PMID: 16501249
DOI: 10.1093/carcin/bgi374

Genes

WRN
BLM
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16501249-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer.PMID 16501249Read ↗

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Rare missense mutations in RECQL and POLG associate with inherited predisposition to breast cancer.Semantic proximity Read ↗

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Mutations in conserved functional domains of human RecQ helicases are associated with diseases and cancer: A review.Semantic proximity Read ↗

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The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C.Semantic proximity Read ↗

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