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Article

Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases.

Ageing research reviews - 1 Jan 2018

Lebel Michel, Monnat Raymond J

Abstract excerpt

Werner syndrome (WS) is a heritable autosomal recessive human disorder characterized by the premature onset of several age-associated pathologies including cancer. The protein defective in WS patients, WRN, is encoded by a member of the human RECQ gene family that contains both a DNA exonuclease and a helicase domain. WRN has been shown to participate in several DNA metabolic pathways including DNA replication,...

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Source

Identifiers

PMID: 29146545
DOI: 10.1016/j.arr.2017.11.003

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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