Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer.

doi:10.3390/ijms161226192

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Article

Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer.

International journal of molecular sciences - 10 Dec 2015

Zins Karin, Frech Barbara, Taubenschuss Eva, Schneeberger Christian, Abraham Dietmar, Schreiber Martin

Abstract excerpt

Like other RECQ helicases, WRN/RECQL2 plays a crucial role in DNA replication and the maintenance of genome stability. Inactivating mutations in RECQL2 lead to Werner syndrome, a rare autosomal disease associated with premature aging and an increased susceptibility to multiple cancer types. We analyzed the association of two coding single-nucleotide polymorphisms in WRN, Cys1367Arg (rs1346044), and Arg834Cys...

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PMID: 26690424
DOI: 10.3390/ijms161226192
PMCID: PMC4691135

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