In vitro and in vivo growth inhibition of murine melanoma K-1735 cell by a dominant negative mutant alpha subunit of the Gi2 protein.

Abstract excerpt

In murine and rat fibroblasts, activation of several G proteins (Gi2, Gq, G12) can stimulate cell growth or transformation, and can induce tumor formation in nude mice; contrastingly, inactivation of Gi2 inhibits fibroblast proliferation in vitro. We investigated whether it is possible to modulate malignant cell growth in vitro and in vivo through alteration of Gi2 protein function. To do so, we introduced...

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