Article
In vitro and in vivo growth inhibition of murine melanoma K-1735 cell by a dominant negative mutant alpha subunit of the Gi2 protein.
Cellular signalling - 1 Mar 1996
Hermouet S, Aznavoorian S, Spiegel A M
Abstract excerpt
In murine and rat fibroblasts, activation of several G proteins (Gi2, Gq, G12) can stimulate cell growth or transformation, and can induce tumor formation in nude mice; contrastingly, inactivation of Gi2 inhibits fibroblast proliferation in vitro. We investigated whether it is possible to modulat...
Topics
- Animals
- Cell Division
- Chemotaxis
- Collagen
- Fibronectins
- GTP-Binding Protein alpha Subunit, Gi2
- GTP-Binding Protein alpha Subunits, Gi-Go
- GTP-Binding Proteins
- Gene Expression
- Growth Inhibitors
- Melanoma
- Mice
- Mice, Nude
- Mutation
- Neoplasm Metastasis
- Proto-Oncogene Proteins
- Transfection
- Tumor Cells, Cultured