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Article

Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.

The Journal of biological chemistry - 29 Feb 2008

Kotzsch Alexander, Nickel Joachim, Seher Axel, Heinecke Kai, van Geersdaele Laura, Herrmann Thomas, Sebald Walter, Mueller Thomas D

Abstract excerpt

Bone morphogenetic proteins regulate many developmental processes during embryogenesis as well as tissue homeostasis in the adult. Signaling of bone morphogenetic proteins (BMPs) is accomplished by binding to two types of serine/threonine kinase transmembrane receptors termed type I and type II. Because a large number of ligands signal through a limited number of receptors, ligand-receptor interaction in the BMP...

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Identifiers

PMID: 18160401
DOI: 10.1074/jbc.M706029200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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