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Article

Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10

3 May 2022

Abstract excerpt

Heterozygous mutations in BMPR2 (bone morphogenetic protein (BMP) receptor type II) cause pulmonary arterial hypertension. BMPRII is a receptor for over 15 BMP ligands, but why BMPR2 mutations cause lung-specific pathology is unknown. To elucidate the molecular basis of BMP:BMPRII interactions, we report crystal structures of binary and ternary BMPRII receptor complexes with BMP10, which contain an ensemble of...

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PMID: 35504921
DOI: 10.1038/s41467-022-30111-2

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