Article

Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension

2019-09-30

Abstract excerpt

Bone morphogenetic proteins (BMPs) are secreted ligands of the transforming growth factor-β (TGF-β) family that control embryonic patterning, as well as tissue development and homeostasis. Loss of function mutations in the type II BMP receptor BMPR2 are the leading cause of pulmonary arterial hypertension (PAH), a rare disease of vascular occlusion and heart hypertrophy. To understand the structural consequences o...

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Literature Corpus work: f79cbc1b-e273-51af-8d85-bf9896d5c3a3
DOI: 10.1101/786756

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