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Article

Cooperativity of binding epitopes and receptor chains in the BMP/TGFbeta superfamily.

Biological chemistry - 1 Aug 2001

Knaus P, Sebald W

Abstract excerpt

Bone morphogenetic proteins (BMP) are dimeric factors initiating several distinct signaling cascades by binding to two types of transmembrane serine/threonine kinase receptors (BRI and BRII), and are thus regulating several steps in embryonal development and adult tissue homeostasis. BMP-2 contains two symmetrical pairs of juxtaposed epitopes: the wrist epitope with high affinity to BRI consists of residues from...

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Identifiers

PMID: 11592400
DOI: 10.1515/BC.2001.149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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