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The Role of E3 Ligase Pirh2 in Disease

30 Apr 2022

Abstract excerpt

The p53-dependent ubiquitin ligase Pirh2 regulates a number of proteins involved in different cancer-associated processes. Targeting the p53 family proteins, Chk2, p27Kip1, Twist1 and others, Pirh2 participates in such cellular processes as proliferation, cell cycle regulation, apoptosis and cellular migration. Thus, it is not surprising that Pirh2 takes part in the initiation and progression of different...

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PMID: 35563824
DOI: 10.3390/cells11091515

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