Article
Ubiquitination of the transcription factor c-MAF is mediated by multiple lysine residues.
The international journal of biochemistry & cell biology - 1 Dec 2014
Chen Guodong, Xu Xin, Tong Jiefei, Han Kunkun, Zhang Zubin, Tang Juan, Li Siyue, Yang Chuanqi, Li Jie, Cao Biyin, Zhou Haixia, Wu Depei, Moran Michael F, Mao Xinliang
Abstract excerpt
The transcription factor c-MAF could be polyubiquitinated and subsequently degraded in the proteasomes. Theoretically, any lysine residues in c-MAF could be ubiquitinated. In the present study, we tried to find out the specific lysine residue(s) mediating c-MAF ubiquitination. Through a series of mutational screens from lysine (K) to arginine (R), we found that any single lysine mutation (K to R) failed to...
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