Article
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation.
Cell - 21 Mar 2003
Leng Roger P, Lin Yunping, Ma Weili, Wu Hong, Lemmers Benedicte, Chung Stephen, Parant John M, Lozano Guillermina, Hakem Razqallah, Benchimol Samuel
Abstract excerpt
The p53 tumor suppressor exerts anti-proliferative effects in response to various types of stress including DNA damage and abnormal proliferative signals. Tight regulation of p53 is essential for maintaining normal cell growth and this occurs primarily through posttranslational modifications of p53. Here, we describe Pirh2, a gene regulated by p53 that encodes a RING-H2 domain-containing protein with intrinsic...
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