Back to search

Article

PJA2 suppresses colorectal cancer progression by controlling HDAC2 degradation and stability.

2023-11-20

Abstract excerpt

<h4>Background: </h4> The Praja Ring Finger Ubiquitin Ligase 2 (PJA2), one of the RING ligase family, has been reported to be degrading differential substrates and regulating diverse diseases. However, the E3 ligase function of PJA2 played in cancer development and progression, especially in colorectal cancer, is still almost unknown. Methods The correlation between PJA2 and clinical characteristics was explored...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8219db89-7d3b-5703-a5b0-3171c1f98e36
DOI
10.21203/rs.3.rs-3592236/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
PJA2 suppresses colorectal cancer progression by controlling HDAC2 degradation and stability.DOI 10.21203/rs.3.rs-3592236/v1
Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancerSemantic proximity
The involvement of E3 ubiquitin ligases in the development and progression of colorectal cancerSemantic proximity
The Role of HECT E3 Ubiquitin Ligases in Colorectal CancerSemantic proximity
ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitinationSemantic proximity
Role of MARCH E3 ubiquitin ligases in cancer developmentSemantic proximity
Cullin-RING Ligase 4 in Cancer: Structure, Functions, and MechanismsSemantic proximity
The Role of E3 Ligase Pirh2 in DiseaseSemantic proximity
Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cellsSemantic proximity
SHARPIN is a novel gene of colorectal cancer that promotes tumor growth potentially via inhibition of p53 expressionSemantic proximity
Beyond destruction: emerging roles of the E3 ubiquitin ligase HakaiSemantic proximity
Aberrant expression of DPPA2 and HIWI genes in colorectal cancer and their impacts on poor prognosisSemantic proximity
Functional roles of E3 ubiquitin ligases in gastric cancer (Review)Semantic proximity
Select a neighboring publication to make it the new centre.