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Pirh2 RING‐finger E3 ubiquitin ligase: Its role in tumorigenesis and cancer therapy

3 Apr 2012

Abstract excerpt

The ubiquitin-dependent proteasome system plays a critical role in many cellular processes and pathogenesis of various human diseases, including cancer. Although there are a large number of E3 ubiquitin ligases, the majority are RING-finger type E3s. Pirh2, a target of p53 transcription factor, contains a highly conserved C(3)H(2)C(3) type RING domain. Importantly, Pirh2 was found to regulate a group of key...

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PMID: 22673504
DOI: 10.1016/j.febslet.2012.03.052

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Pirh2 RING‐finger E3 ubiquitin ligase: Its role in tumorigenesis and cancer therapyPMID 22673504Read ↗

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