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Article

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.

Nature cell biology - 1 Jan 2010

Bekker-Jensen Simon, Rendtlew Danielsen Jannie, Fugger Kasper, Gromova Irina, Nerstedt Annika, Lukas Claudia, Bartek Jiri, Lukas Jiri, Mailand Niels

Abstract excerpt

Regulatory ubiquitylation is emerging as an important mechanism to protect genome integrity in cells exposed to DNA damage. However, the spectrum of known ubiquitin regulators of the DNA damage response (DDR) is limited and their functional interplay is poorly understood. Here, we identify HERC2 as a factor that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. In response to...

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Source

Identifiers

PMID: 20023648
DOI: 10.1038/ncb2008

Genes

HERC2
RNF8
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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