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Article

Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer.

Inflammatory bowel diseases - 1 Sept 2011

Sanchez Julian A, Dejulius Kathryn L, Bronner Mary, Church James M, Kalady Matthew F

Abstract excerpt

BACKGROUND: Chronic ulcerative colitis (UC) is associated with an increased colorectal cancer risk which may be secondary to repetitive mucosal injury. Both epigenetic methylation and the classic adenoma-to-carcinoma sequence have been implicated in this malignant transformation, but the underlying molecular mechanisms remain poorly defined. This study compares the molecular characteristics of colitis-associated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21618350
DOI: 10.1002/ibd.21526

Genes

BRAF
KRAS
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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