Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma.

doi:10.1158/1078-0432.CCR-07-1802

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Article

Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2008

Suehiro Yutaka, Wong Chi Wai, Chirieac Lucian R, Kondo Yutaka, Shen Lanlan, Webb C Renee, Chan Yee Wai, Chan Annie S Y, Chan Tsun Leung, Wu Tsung-Teh, Rashid Asif, Hamanaka Yuichiro, Hinoda Yuji, Shannon Rhonda L, Wang Xuemei, Morris Jeffrey, Issa Jean-Pierre J, Yuen Siu Tsan, Leung Suet Yi, Hamilton Stanley R

Abstract excerpt

PURPOSE: Early events in colorectal tumorigenesis include mutation of the adenomatous polyposis coli (APC) gene and epigenetic hypermethylation with transcriptional silencing of the O(6)-methylguanine DNA methyltransferase (MGMT), human mut L homologue 1 (hMLH1), and P16/CDKN2A genes. Epigenetic alterations affect genetic events: Loss of MGMT via hypermethylation reportedly predisposes to guanine-to-adenine or...

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Identifiers

PMID: 18451217
DOI: 10.1158/1078-0432.CCR-07-1802
PMCID: PMC3544184

Genes

APC
MGMT
BRAF
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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