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Article

Global transcription machinery engineering: a new approach for improving cellular phenotype.

Metabolic engineering - 1 May 2007

Alper Hal, Stephanopoulos Gregory

Abstract excerpt

It is now generally accepted that most cellular phenotypes are affected by many genes. As a result, engineering a desired phenotype would be facilitated enormously by simultaneous multiple gene modification, yet the capacity to introduce such modifications is very limited. Here, we demonstrate that the components of global cellular transcription machinery (specifically, sigma(70)) can be engineered to allow for...

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Identifiers

PMID: 17292651
DOI: 10.1016/j.ymben.2006.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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