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Article

Customized optimization of metabolic pathways by combinatorial transcriptional engineering.

Nucleic acids research - 1 Oct 2012

Du Jing, Yuan Yongbo, Si Tong, Lian Jiazhang, Zhao Huimin

Abstract excerpt

A major challenge in metabolic engineering and synthetic biology is to balance the flux of an engineered heterologous metabolic pathway to achieve high yield and productivity in a target organism. Here, we report a simple, efficient and programmable approach named 'customized optimization of metabolic pathways by combinatorial transcriptional engineering (COMPACTER)' for rapid tuning of gene expression in a...

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Identifiers

PMID: 22718979
DOI: 10.1093/nar/gks549
PMCID: PMC3467037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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