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Article

Engineering yeast transcription machinery for improved ethanol tolerance and production.

Science (New York, N.Y.) - 8 Dec 2006

Alper Hal, Moxley Joel, Nevoigt Elke, Fink Gerald R, Stephanopoulos Gregory

Abstract excerpt

Global transcription machinery engineering (gTME) is an approach for reprogramming gene transcription to elicit cellular phenotypes important for technological applications. Here we show the application of gTME to Saccharomyces cerevisiae for improved glucose/ethanol tolerance, a key trait for many biofuels programs. Mutagenesis of the transcription factor Spt15p and selection led to dominant mutations that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17158319
DOI: 10.1126/science.1131969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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