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Article

Using transcription machinery engineering to elicit complex cellular phenotypes.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Lanza Amanda M, Alper Hal S

Abstract excerpt

Cellular hosts are widely used for the production of chemical compounds, including pharmaceutics, fuels, and specialty chemicals. However, common metabolic engineering techniques are limited in their capacity to elicit multigenic, complex phenotypes. These phenotypes can include non-pathway-based traits, such as tolerance and productivity. Global transcription machinery engineering (gTME) is a generic methodology...

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PMID: 22083746
DOI: 10.1007/978-1-61779-412-4_14

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