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Article

Multiplex navigation of global regulatory networks (MINR) in yeast for improved ethanol tolerance and production.

Metabolic engineering - 1 Jan 2019

Liu Rongming, Liang Liya, Choudhury Alaksh, Garst Andrew D, Eckert Carrie A, Oh Eun Joong, Winkler James, Gill Ryan T

Abstract excerpt

Multiplex navigation of global regulatory networks (MINR) is an approach for combinatorially reprogramming gene expression to manipulate complex phenotypes. We designed, constructed, and mapped MINR libraries containing 43,020 specific mutations in 25 regulatory genes expected to perturb the yeast regulatory network. We selected growth competition experiments for library mutants conferring increased ethanol...

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PMID: 30030154
DOI: 10.1016/j.ymben.2018.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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