Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efficient protein production by yeast requires global tuning of metabolism.

Nature communications - 25 Oct 2017

Huang Mingtao, Bao Jichen, Hallström Björn M, Petranovic Dina, Nielsen Jens

Abstract excerpt

The biotech industry relies on cell factories for production of pharmaceutical proteins, of which several are among the top-selling medicines. There is, therefore, considerable interest in improving the efficiency of protein production by cell factories. Protein secretion involves numerous intracellular processes with many underlying mechanisms still remaining unclear. Here, we use RNA-seq to study the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbohydrate Metabolism
Share to Endoplasmic Reticulum Stress
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Industrial Microbiology

Share to Recombinant Proteins

Share to Thiamine

Share to Transcriptome

Share to Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 29070809
DOI: 10.1038/s41467-017-00999-2
PMCID: PMC5656615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efficient protein production by yeast requires global tuning of metabolism.PMID 29070809Read ↗

Design of the biosensor-dependent coupling system stabilizes the high-synthesis phenotype of cell factory.Semantic proximity Read ↗

Ribo-seq guided design of enhanced protein secretion in <i>Komagataella phaffii</i>Semantic proximity Read ↗

Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretionSemantic proximity Read ↗

Understanding and eliminating the detrimental effect of endogenous thiamine auxotrophy on metabolism of the oleaginous yeast <i>Yarrowia lipolytica</i>Semantic proximity Read ↗

Model-driven analysis reveals oxidative stress adaptation enabling efficient energy utilization in a Crabtree-negative Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast adapts to diverse ecological niches driven by genomics and metabolic reprogrammingSemantic proximity Read ↗

Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeastSemantic proximity Read ↗

Quantitative Operating Principles of Yeast Metabolism during Adaptation to Heat Stress.Semantic proximity Read ↗

The impact of phosphate scarcity on pharmaceutical protein production in S. cerevisiae: linking transcriptomic insights to phenotypic responses.Semantic proximity Read ↗

Exploration of essential gene functions via titratable promoter alleles.Semantic proximity Read ↗

Genome-wide analysis of yeast stress survival and tolerance acquisition to analyze the central trade-off between growth rate and cellular robustness.Semantic proximity Read ↗

Carbon source-driven metabolic and regulatory remodeling defines phenomic states in Lipomyces starkeyi.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.