Article
Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates.
BMC genomics - 7 Feb 2007
Kraemer Susan M, Kyes Sue A, Aggarwal Gautam, Springer Amy L, Nelson Siri O, Christodoulou Zoe, Smith Leia M, Wang Wendy, Levin Emily, Newbold Christopher I, Myler Peter J, Smith Joseph D
Abstract excerpt
BACKGROUND: Var genes encode a family of virulence factors known as PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1) which are responsible for both antigenic variation and cytoadherence of infected erythrocytes. Although these molecules play a central role in malaria pathogenesis, the mechanisms generating variant antigen diversification are poorly understood. To investigate var gene evolution, we...
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